Eur J Neurosci 11(9):31993214 Travaglione V, Peacock C, MacDougall J, McGovern K, Cushing J, Yu LC, Trudeau M, Palombella V, Adams J, Hierman J, Rhodes J (2008) A novel HH pathway inhibitor, IPI-926, delays recurrence post-chemotherapy in a primary human SCLC xenograft model Tremblay MR, Lescarbeau A, Grogan MJ, Tan E, Lin G, Austad BC, Yu LC, Behnke ML, Nair SJ, Hagel M, White K (2009) Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
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This article reviews: Definition Mechanism of action Experimentally observed benefits Dosages used in scientific studies Reported side effects in laboratory settings All references below relate to experimental or preclinical research models
Even short exposures can reduce stability, especially for reconstituted solutions
