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The mechanism appears to involve altered dopamine signaling in brain reward pathways

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Abbreviations ALT: Alanine transaminase AST: Aspartate transaminase AUC 0- : Area under the concentration-time curve BMI: Body mass index C max : Peak plasma concentration CTCAE: Common Terminology Criteria for Adverse Events CYP: Cytochrome P450 GLP-1: Glucagon-like peptide-1 HbA1c: Glycated hemoglobin SU: Sulfonylurea T-Bil: Total bilirubin References Kawamori R, Kaku K, Hanafusa T, Kashiwabara D, Kageyama S, Hotta N

It means we have a window to intervene before it becomes one. Framed this way, patients find the information empowering rather than frightening

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