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The thresholds reported in preclinical literature vary: PCB-157 : 10 g/kg to 1 mg/kg subcutaneously or intraperitoneally depending on the model

Ultra-high-temperature milk (UHT, heated for 145 C/5 s) and yoghurt (heated for 90 C/10 min before inoculation) lose their FBP through denaturation due to high processing temperatures

A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

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Interestingly, auto Abs to GSTT1 were also able to home in the graft and likely contribute to ABMR and kidney dysfunction in the absence of intragraft HLA-DSAs