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Omega-3 Fatty Acids and Atrial Fibrillation

10.1016/j.thromres.2011.07.035 66 StupnisekM.KokotA.DrmicD.Hrelec PatrljM.Zenko SeverA.KolencD.et al (2015)

Similarly, serotonin levels are significantly lower in the model group, indicating a potential sleep disorder

This ferroptosisinflammationhypoxia loop ultimately converges on fibrosis progression: pro-inflammatory cytokines (e.g., from activated macrophages) and hypoxic signals synergistically activate the TGF-/SmadHDAC3 pathway, downregulating anti-fibrotic Klotho and upregulating pro-fibrotic factors (e.g., collagen I/III)

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