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These findings are specific to controlled animal models and are used to better understand how NNMT and related pathways influence energy storage and utilization, not to support clinical or therapeutic conclusions

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As the flowchart shows, testing is the starting line

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Although some clinical trials are in progress, due to severe side effects such as those caused by an undesired pharmacological activity, suppression of the innate immune response to viral and bacterial infections, and damage to the central nervous system and liver, 244,245 these drugs remain challenging for a clinical application

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