In the ACHIEVE-3 head-to-head against oral semaglutide in T2D, 36 mg orforglipron produced about 9.2% body weight reduction versus about 5.3% on 14 mg oral semaglutide, and superior HbA1c reduction
Lehmann ED, Cockerell OC, Rudge P
In addition, the injectable medications need to be refrigerated and arent as easy to transport as pills to locations away from home
This is because hemoglobin A1C (a measure of blood sugar control) and sex hormone-binding globulin (SHBG) are inversely correlated: as A1C improves with weight loss, SHBG levels may rise, which can bind more testosterone and reduce the amount that circulates freely in the bloodstream
Chilis has had a well-publicized comeback over the last two years, and for GLP-1 users, the upgraded menu is actually good news