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In the context of cerebral ischemia, astrocytes are especially important in regulation and maintenance of glutamate during acute injury, which causes excitotoxicity and perturbates calcium influx resulting in cell death ( Per2, Clock , and NPAS2 display significant reductions in glutamate uptake, mRNA expression of Glast, an astrocyte-specific glutamate transporter, and protein expression (Sofroniew, 2015)

References Heymsfield, S

Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein -synuclein

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