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doi: 10.1016/j.ajpath.2019.10.008 52 BaggioLLDruckerDJ

In addition to the direct impact on the proportion of gut bacteria, GLP-1RAs were found to upregulate tight junction proteins in the intestinal mucosa, which helps prevent the translocation of bacteria to the blood

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After the initial baseline challenge, subjects were placed on a week-long oral regimen of a cocktail of poorly absorbed antibiotics previously shown to effectively suppress intestinal microbiota (6), and then the d 3 -l-carnitine challenge was repeated (Figure 1, open circles)