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Quick Answer: Most healthy adults can take glutathione safely, but pregnant or breastfeeding women and those with specific respiratory sensitivities should exercise caution

Substance P released in TBI or under stress, activates mast cells, microglia and astrocytes, and releases additional neuroinflammatory mediators that increase BBB permeability (Corrigan et al., 2016)

Use body surface area (BSA) normalization, not direct mg/kg conversion a 5mg/kg oral dose in a 250g rat translates to approximately 0.4mg/kg in a 70kg human, or 28mg total dose

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Healthy populations of Lactobacillus acidophilus, Bifidobacterium longum, and other commensals competitively exclude Candida through bacteriocin production, pH regulation, and immune priming