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Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162

Norton, L., Shannon, C., Gastaldelli, A

3 It affects more than 700 million people worldwide 4 and leads to the destruction of bone and soft tissue, as well as systemic inflammatory manifestations

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Each infusion is administered by a licensed medical professional, with treatment options determined based on patient needs and clinical appropriateness