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The GLP-1 receptor was first identified by ligand binding experiments and measurements of cyclic AMP accumulation using the rat insulinoma cell line

10.1021/bi401457r Biochemistry 52 ChowdhuryS.OtomoC.LeitnerA.OhashiK.AebersoldR.LanderG

Although glucagon is traditionally understood as a counter-regulatory hormone that increases hepatic glucose production, its pharmacologic activation in balanced multi-receptor agonists may contribute to weight reduction by increasing energy expenditure, promoting fatty acid oxidation, and improving hepatic lipid metabolism