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Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation

Certain herbs may be classified as "therapeutic goods", in Australia, requiring registration or approval

Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP

Other peptide-based medications are widely used for conditions like diabetes, multiple sclerosis, and cancer

While additional studies are needed to determine whether elevated vitamin B 12 status may be related to cancer development, including evaluating whether it might be a potential marker of cancer, it is important for observational studies to adequately control for potential confounders, such as age, menopausal status, alcohol use, and intake of the B-vitamin folate