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Retrieved 18 May 2007

AOD9604, an analog of hGH fragment 177191, reduces body weight in obese mice but not obese humans. Int J Obes Relat Metab Disord

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Its expression during neonatal period has to be finely regulated

Several factors contribute, including: Lower estrogen affecting fat distribution and insulin sensitivity Age-related muscle loss reducing metabolic rate Increased cortisol responses during stress and poor sleep Greater blood sugar fluctuations leading to stronger cravings Slower digestion and decreased satiety signals after meals These changes create a situation where women can eat well, exercise, and still struggle with weight gain or stalled progress