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This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder

This could explain why bile acid sequestrants support a positive glucometabolic homeostasis

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Owing to this structure, liposomes bond easily with cell membranes to facilitate intracellular delivery of their nutrient cargo