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Mod Pathol 22(1):151160 Hafner C et al (2003) Loss of EphB6 expression in metastatic melanoma

Defined as pain lasting three months or longer, it can manifest as localized discomfort from muscle strain or degenerative disc disease, or as radiating pain (lumbar radiculopathy) with numbness, tingling, or weakness, often due to nerve root compression

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Use raw HR for this calculation, not placebo-subtracted (placebo arm shows real cardiovascular adaptation from weight loss + lifestyle counseling, so subtraction over-corrects for drug-attributable cost)