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Its the main ingredient in three medications approved by the Food and Drug Administration (FDA): While Ozempic has become increasingly popular for weight loss, its approved only for managing type 2 diabetes

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Moreover, GLP-1 could down-regulate ANG II production at tissue level (71) indeed reported that chronic treatment with GLP-1RA exendin 4 (Ex4) in rats decreased renal cortical ANG II content and urinary excretion of AGT, while blockade of GLP-1 receptor with exendin 9 (Ex9) exerted opposite effects

doi: 10.1093/ajcn/88.4.906

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