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In the presence of redox-active transition metals, VC exhibits pro-oxidant effects, inducing oxidative stress through the formation of ROS or by inhibiting the antioxidant system (39, 97)

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To advance, future studies should focus on delineating specific on-target effects using validated chemical probes, conducting rigorous ADME (Absorption, Distribution, Metabolism, Excretion) studies, and prioritizing agents with favorable therapeutic indices for preclinical development

The study found no significant differences between the two treatment regimens