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Esomeprazole and aspirin in Barretts oesophagus (AspECT): a randomised factorial trial

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Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported in part by (i) the Technological Innovation R&D Program (S2174574) funded by the Small and Medium Business Administration (Republic of Korea)

In conclusion, the paper provides evidence that the reduction of GLP-1+ cells is a general feature of ileal and colonic inflammation in mice and humans and is likely due to altered epithelial differentiation driven by changes in cellular metabolism, particularly mitochondrial dysfunction.