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When any antioxidant, including glutathione, retains all its electrons (making the number of protons and electrons in the molecule equal), it is in a reduced state

It may develop because of a mix of factors, such as: Family history of anxiety Brain chemistry and biology Long-term stress Trauma or difficult life events Major life changes High-pressure work, school, or family situations Other mental health conditions, such as depression or panic disorder Some people may feel they have always been a worrier, while others may notice anxiety after a stressful event or major life change

Neuroscience 72, 641653 (1996)

[SOURCED] Musculoskeletal and Tendon Models Staresinic et al

Treatment response evaluation should focus on objective measures relevant to the specific indication being treated