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The reduction in blood pressure in D 2 / mice caused by etamicastat correlates with an increase in the DA/NE content in heart and urine (but not kidney) and D 1 R expression in the kidney, as well as a normalization of renal NOX isoforms (NOX1 and NOX2) and proximal tubule NHE3 and a decrease in distal convoluted tubule NCC

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This rapid elimination means frequent supplementation is essential to maintain therapeutic levels