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In many disease states, such as metabolic syndrome, inflammatory bowel disease (IBD), cardiovascular diseases, malignant tumors, etc., the structure and function of intestinal microbiota are obviously different from those of healthy bowel microbiota (Tilg and Moschen, 2014

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In the embryonic mouse hypothalamic cell line mHypoE-N41, bile acids stimulate TGR5 via the Rho/Rho-associated protein kinase pathway (Fig

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