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For surgical implantation of the ICV cannula, mice were anaesthetised with 34% isoflurane (inhalation) during surgery and were given analgesic (carprofen, 5 mg kg 1 ) and supplemental fluids (lactated Ringers solution

Only 4.3% of participants discontinued treatment entirely due to gastrointestinal side effects

Furthermore, extreme outlier samples were excluded from the analysis to minimize potential biases and confounding factors, ensuring the study remains focused on the intended research objectives

Weeks 13 and beyond (1.0 to 2.4 mg maintenance) Once you reach your maintenance dose, your body has adapted and eating patterns stabilize

Creams: Offer additional moisturizing benefits and may be better suited for individuals with dry skin types or those who prefer a single-step approach