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Unlike GLP-1 agonists, it preserves lean muscle mass during caloric restriction

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It is also for people with a body mass index greater than or equal to 30 kg/m2 or a body mass index greater than or equal to 27 kg/m2 and other risk factors (e.g., controlled high blood pressure, diabetes, high cholesterol)

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Once the pen is opened, even if it was previously refrigerated, the storage instructions change to room temperature with a much shorter lifespan, as detailed in the How long can semaglutide stay out of the fridge? section