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Metformin has generally not demonstrated its anticipated benefits in most clinical trials in nondiabetic populations A contemporary evaluation of this literature reveals emerging uncertainty about the anti-aging potential of Metformin

doi: 10.1056/NEJMoa1901118 55 RosenstockJAllisonDBirkenfeldALBlicherTMDeenadayalanSJacobsenJBet al

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Fasting-refeeding Wild-type, iDTR, or iDTR:: Pomc -Cre mice were subjected to an overnight fast (16 hours) before receiving an i.c.v