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Key symptoms Loose, watery stools Increased frequency of bowel movements Urgency to defecate Abdominal cramping or pain Possible nausea Bloating or gas Risk of dehydration and electrolyte imbalances if severe How common is diarrhoea with GLP-1 treatments

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

These observations were corroborated by single-cell calcium imaging studies in slices of arcuate nuclei, demonstrating that GLP-1MK-801 inhibits the NMDA-induced intracellular calcium surge relative to GLP-1 alone (Extended Data Fig

A., Pfeifer, M

TB-500: No significant meal timing requirements