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Hershey's CEO, Kirk Tanner, has spoken about how the rapid uptake of GLP-1 drugs is contributing to strong sales, particularly for their mint and chewing gum brands

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Nevertheless, several challenges remain, including the need for deeper mechanistic clarification, high-quality multicenter clinical evidence, systematic evaluation of long-term safety and drug interactions, and standardized criteria for personalized treatment

So, for example, 8M urea or 6M guanidine HCl would likely denature GST, preventing the GST-glutathione interaction that serves as the foundation for this purification