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Ischemia-selective cardioprotection by malonate for ischemia/reperfusion injury

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Actin plays a vital role in keeping the structural and functional integrity of cells intact, especially in muscle cells

250,251,252 UA induced inflammation and relative mechanism Uric acid signaling triggers the activation of several transcription factors, such as NF-B or AP-1, through the activation of MAPK p38 and ERK pathways, resulting in the production of reactive oxygen species (ROS) under the conditions of hyperuricemia

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