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We hope this review can inspire the design and fabrication of PIPN-tailored drug and nanosystems for prevention and individualized treatment to raise the clinical benefits in patients treated with Pt-based chemotherapy

[10] [12] High-dose ascorbic acid may diminish the therapeutic effects of certain chemotherapeutic agents, such as bortezomib, due to its antioxidant properties

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Once you start pushing toward 2,000mg or higher, the risk of side effects increases without necessarily providing additional benefits