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Additional antioxidant pathways, including the GTP cyclohydrolase 1 (GCH-1)-tetrahydrobiopterin (BH4) pathway and the ferroptosis suppressor protein 1 (FSP1)-ubiquinone (CoQ)-NADPH pathway, also play vital roles in ferroptosis regulation

Diagnostically, BED requires recurrent binge episodeseating an unusually large amount with a sense of loss of controloccurring, on average, at least weekly over three months, associated with marked distress and with features such as eating rapidly, eating past fullness, eating when not hungry, eating alone from embarrassment, and feeling disgust or guilt afterward

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