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Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance

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The SURMOUNT-1 72-week clinical trial showed those taking tirzepatide lost an average of 16.0% of their body weight on the 5 mg dose, 21.4% on the 10 mg dose, and 22.5% on the 15 mg dose, compared to 2.4% with placebo