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Generally, the GLP-1RAs also lower blood pressure

Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of hydrocodone bitartrate and acetaminophen tablets and/or precipitate withdrawal symptoms

It is also listed as a prohibited agent by the US Department of Defense/War as well as by the World Anti-Doping Agency (WADA)

They can suggest an adjustment to the dosage or timing of the drug or potentially recommend an alternative drug

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