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They also rise significantly during calorie restriction, which is one of the core reasons dieting becomes harder over time: the longer you restrict your intake, the more your body pushes back with elevated hunger signals
[2] [7] These findings led regulatory authorities, including the Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA), to include specific warnings and precautions in the prescribing information for all GLP-1 medications
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Footnotes These authors contributed equally to the present review
GLP-1 medications such as semaglutide and tirzepatide are commonly used to support weight loss by helping regulate appetite and food intake
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