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Whole-cell voltage-clamp recordings revealed that the amplitude of NMDA receptor-mediated tonic currents in the FG + DMV neurons were significantly decreased in the taCaspase3 group compared to control group (Supplementary Fig

The slower transit time means stool remains in the colon longer, causing it to become harder and more difficult to pass

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Results: Single cell RNAseq analysis showed that Cav1.3 deletion alters -cell gene transcription suppressing cell-differentiation and activating protein degradation pathways

Long-term maintenance and continued progress are also possible with ongoing therapy, healthy nutrition, and regular physical activity