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However, kidney function declines with age, which affects clearance of some peptides

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This review builds upon the canonical hypothesis of oncogene-induced senescence in growth arrest and tumor suppression in melanocytic nevi and melanoma

Notably, CYP27B1 is also expressed in extra-renal tissues such as the placenta and prostate, where it facilitates local synthesis of 1,25(OH)D to modulate cellular functions via paracrine or autocrine signaling [96, 99]