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Human TMPRSS2, an enzyme widely expressed in several human cells, acts on the S2 prime (S2) region, and cleaves the S-protein 75

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Orforglipron represents a different class: a small molecule GLP-1 drug that: Does not require refrigeration Has no food or beverage restrictions Can be manufactured and scaled more efficiently These advantages could make orforglipron particularly impactful in low- and middle-income countries, where access to injectable medications can be limited due to cost or storage requirements