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Large areas of clinical practice in type 1 diabetes are based on expert opinion and cohort studies rather than RCTs and so the writing group considered both observational and clinical trial findings, rather than relying solely on unbiased RCTs and meta-analyses

DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure

The same benefit terms must apply to all similarly situated individuals in a class of employees