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GLP-1 Therapies Move Into the Pharmaceutical Mainstream GLP-1 receptor agonists, led by semaglutide (Wegovy) and tirzepatide (Zepbound), have significantly changed expectations for pharmacological weight loss

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To inactivate LS GLP-1R neurons, we injected AAV expressing double-floxed EGFP and TeNT (AAV-DIO-EGFP-2A-TeNT) into the bilateral LS of GLP-1R-ires-Cre mice to achieve specific expression of EGFP-2A-TeNT in LS GLP-1R neurons (Figure 3A and Supplemental Figure 6C)

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Signs of uncontrolled hyperglycaemia, such as excessive thirst, frequent urination, or the presence of ketones in urine or breath