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Gene therapy studies using HGF have demonstrated beneficial effects in animal models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and cerebral ischemia, with HGF treatment promoting neurite extension, increasing synaptogenesis, and enhancing functional recovery

Certain patients benefit from soluble fiber supplementation, dietary fat modulation, or extended spacing between dose increases

CaD (WHI) = calcium plus vitamin D intervention

Wang Q, Lin H, Shen C, et al

The MAPK/ERK signaling cascade primarily mediates cellular proliferation, while the PI3K/AKT pathway predominantly regulates cell survival and apoptosis (Macvanin et al., 2023