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Second, neurodegenerative indications highlight a similar gap between mechanistic promise and clinical outcomes

At the higher doses, results were very consistent: All participants lost at least 5% of their body weight Around 3 in 4 lost 15% or more With placebo, only around 1 in 4 lost 5% or more Phase 3 update (TRIUMPH-4, 68 weeks, topline results) In December 2025 , Eli Lilly shared early (topline) results from a larger phase 3 study (TRIUMPH-4)

Dermatologic Surg Off Publ Am Soc Dermatologic Surg [et al]

Wang J, Jones SM, Pongracic JA, Song Y, Yang N, Sicherer SH et al (2015) Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy

Boehmer AL, Brinkmann AO, Niermeijer MF, Bakker L, Halley DJ, Drop SL