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Its levels in the body can be reduced due to aging, poor diet, chronic illness, or exposure to environmental toxins

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For methylene blue, this precision is especially importanttoo little may limit effectiveness, while too much can increase the risk of side effects

Gastrointest Endosc 2009;69:1120-1128

This situation is also accompanied by the altered efficacy of G-protein stimulation in opioid-sensitive CNS structures and a reduction in the expression of several opioid receptor mRNAs, which indicates that NP can recruit and modify several opioidergic circuits in the brain [139]