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The nitrile forms a covalent imidate with the hydroxyl group of Ser630, which subsequently forms a hydrogen bond with the hydroxyl side group of Tyr547

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However, a 2025 meta-analysis, which included more than 84,000 participants across 34 studies, found that people taking GLP-1s were 3.4 times more likely to experience hair loss compared with people not taking the drugs

Depression, a mood disorder characterized primarily by persistent feelings of sadness and anhedonia, arises from diverse causes

10.1002/jcsm.13722 J