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BAT is a metabolically active fat tissue that generates heat by uncoupling the mitochondrial proton gradient essentially running the cellular energy production process "backwards" to generate heat rather than ATP

Nazary-vannani A, Ghaedi E, Mousavi SM, Teymouri A, Rahmani J, Varkaneh HK

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Dysfunction in GLP-1R signaling has been implicated in multiple pathologies, including type 2 diabetes mellitus (T2DM), obesity, atherosclerosis, Parkinsons disease (PD), Alzheimers disease (AD), non-alcoholic steatohepatitis (NASH), and several cancers

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