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Pediatric Patients without Type 2 Diabetes In a 56-week placebo-controlled clinical trial of pediatric patients without type 2 diabetes mellitus in which blood glucose meters were provided, 19 (15.2%) of SAXENDA-treated patients had hypoglycemia with a blood glucose less than 70 mg/dL with symptoms as compared to 5 (4%) of placebo-treated patients

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EC 50 : 2.6 nM5 nM).25 Changing GIP Ile 17 to Ala massively lowered the insulinotropic effect.27 The Ile 17 from GIP chosen in tirzepatide may be important to GIP activity but could cause a decline in GLP-1 activity