Pajaud J, Kumar S, Rauch C et al (2012) Regulation of signal transduction by glutathione transferases
DOX increased nitrotyrosine abundance by 68% compared to controls, reflecting heightened oxidative stress
REDOX imbalance is typically measured via plasma glutathione, as glutathione is critical to the adaptive antioxidant response in the brain
This is the second rejection for remestemcel-L, after the FDA first turned down Mesoblasts application in 2020, despite a 9-1 advisory committee vote in its favor
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