Most dermatologists say you might see some mild brightening if you take it regularly, but dont expect dramatic changes

Drugs that may increase the risk of hypoglycemia : antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, and SGLT-2 inhibitors Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones Drugs that may increase or decrease the blood glucose lowering effect : alcohol, beta-blockers, clonidine, lithium salts, and pentamidine Drugs that may blunt the signs and symptoms of hypoglycemia : beta-blockers, clonidine, guanethidine, and reserpine Please click here for Tresiba Prescribing Information

6.2 Estrogen deficiency accelerates skin aging
Parvathaneni V, Kulkarni NS, Muth A, Gupta V
4C / 39F Recommended for short-term peptide storage over weeks to months