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The peptide demonstrates dual-phase mechanisms: acute phase preservation of ischemic tissue through anti-apoptotic signaling via Akt activation, and chronic phase activation of cardiac progenitor cells (c-kit+ populations) that contribute to myocardial repair through both structural replacement and paracrine support, with studies showing 200% increases in progenitor cell mobilization and cardiac homing

S-glutathionylation involves the covalent attachment of glutathione (GSH) to protein thiols, forming mixed disulfide bonds that protect key enzymatic sites and maintain redox homeostasis

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PMID: 2995861