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Hepatokines predominantly function as liver-derived pro-inflammatory mediators, exerting a pivotal role in the promotion of liver steatosis and steatohepatitis through their influence on lipid metabolism, reactive oxygen species generation, and the inflammatory response

This regulatory decision has been taken after expert committee evaluations concluded that these combinations lack adequate therapeutic justification and may pose potential risks to patient safety

Cirino G, Szabo C, Papapetropoulos A

As mentioned above, there may be a close association among ferroptosis, autophagy, apoptosis, and necrosis in testicular diseases

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