The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea
In contrast, commensal colonizer lineages, such as cc53, have not acquired these GIs and are characterized by thirteen unique loss-of-function loci (Mullally et al., 2021)
found that both cI and cIV were deficient in the remaining dopaminergic synapses of idiopathic PD (Reeve et al., 2018)
For instance, in post mortem studies in the human brain from Alzheimers disease patients, it was demonstrated that the Se distribution pattern in the brain is seriously distorted (Rueli et al., 2015)
One of the few studies that utilized exogenous glutathione used a combination of 1 g glutathione with 2 g vitamin C (another well-established antioxidant) daily for 7 days in trained athletes to test the possible effect on exercise-induced glutathione oxidation