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Mojca Jensterle from the University Medical Center Ljubljana points out a key issue: The major concern is how to balance the reproductive and metabolic treatment strategies since the use of GLP-1 receptor agonists requires effective contraception while on therapy and a washout period before pregnancy

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It may be that patients with these factors are more likely to suffer onset and transformation of melanocytic nevi after taking Melanotan, with a potentially increased risk of developing melanoma

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