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Particles from the best-looking class (1.21 million and 1.72 million particles of PF-06882961 and OWL833 complex, respectively) were subjected to Bayesian particle polishing, CTF refinement and cycles of 3D auto-refinement in RELION (Zivanov et al., 2018)

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Both therapies target different biological systems, and combination use often produces complementary metabolic benefits including superior fat loss while preserving muscle

This interaction leads to the retention of Yap1 in the nucleus to upregulate oxidative responsive genes 61,62